Some organs appear to mount a preemptive defense against lipotoxicity.
Heart Receives SOS From Fat Cells, Builds Defense Against Obesity Eventualities: Study
WASHINGTON — The heart receives a stress signal from fat cells and immediately builds a defense against a syndrome that results in cellular dysfunction and death, according to a new study led by researchers at the University of Texas Southwestern Medical Center.
The findings—published online in Cell Metabolism—could help explain the “obesity paradox,” a phenomenon in which obese individuals have better short- and medium-term cardiovascular disease prognoses compared with those who are fitter but with ultimately worse long-term outcomes.
“The mechanism we have identified here could be one of many that protect the heart in obesity,” said study leader Philipp E. Scherer, professor of internal medicine and cell biology at the University of Texas Southwestern Medical Center who has long studied fat metabolism.
Study co-leader Clair Crewe, assistant instructor of internal medicine at the medical school, explained that the metabolic stress of obesity gradually makes fat tissue dysfunctional, causing its mitochondria—the cellular organelles that generate energy—to shrink and die.
Eventually, this unhealthy fat loses the ability to store lipids generated by excess calories in food, poisoning other organs through an effect called lipotoxicity.
Some organs—including the heart—appear to mount a preemptive defense to protect against lipotoxicity. But how the heart senses fat’s dysfunctional state has been unknown.
In their study, Crewe, Scherer, and their colleagues used a genetic technique to speed the loss of mitochondrial mass and function in mice. When these animals ate a high-fat diet and became obese, the researchers found that the rodents’ fat cells began sending out extracellular vesicles filled with small pieces of dying mitochondria.
Some of these mitochondrial snippets traveled through the bloodstream to the heart, triggering oxidative stress—a state in which cells generate harmful free radicals.
To counteract this stress, heart cells produce a flood of protective antioxidant molecules. This protective backlash was so strong that when the scientists injected mice with extracellular vesicles filled with mitochondrial snippets and later induced a heart attack, the animals had significantly less damage to their hearts compared with mice that didn’t receive an injection.
Further research using fat tissue sampled from obese patients showed that these cells also release mitochondria-filled extracellular vesicles, suggesting that the effects observed in mice also take place in humans, according to Crewe.
Eventually, the heart and other organs in obese individuals become overwhelmed by lipotoxic effects, leading to many of obesity’s comorbidities. However, learning how to artificially generate the protective mechanism identified in this study could lead to new ways to buffer obesity’s negative consequences.
This knowledge could even suggest strategies to protect the heart against damage in lean individuals as well.
“By better understanding the distress signal from fat, we may be able to harness the mechanism to improve heart health in obese and non-obese individuals alike,” said Crewe.
(With inputs from ANI)
Edited by Amrita Das and Krishna Kakani